Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.

doi:10.1006/geno.1994.1661

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Article

Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.

Genomics - 1 Dec 1994

Kolodner R D, Hall N R, Lipford J, Kane M F, Rao M R, Morrison P, Wirth L, Finan P J, Burn J, Chapman P

Abstract excerpt

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is a major cancer susceptibility syndrome known to be caused by inheritance of mutations in genes such as hMSH2 and hMLH1, which encode components of a DNA mismatch repair system. The MSH2 genomic locus has been cloned and shown to cover approx...

Topics

Amino Acid Sequence
Base Sequence
Chromosomes, Human, Pair 2
Cloning, Molecular
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA
DNA Mutational Analysis
DNA Primers
DNA-Binding Proteins
Exons
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Frameshift Mutation

Genetic Linkage

Humans

Introns

Male

Molecular Sequence Data

MutS Homolog 2 Protein

Source

Open in PubMed

Identifiers

PMID: 7713503
DOI: 10.1006/geno.1994.1661

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7713503-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.PMID 7713503Read ↗

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