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Article

Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.

Genomics - 1 Dec 1994

Kolodner R D, Hall N R, Lipford J, Kane M F, Rao M R, Morrison P, Wirth L, Finan P J, Burn J, Chapman P

Abstract excerpt

Hereditary nonpolyposis colorectal carcinoma (HNPCC) is a major cancer susceptibility syndrome known to be caused by inheritance of mutations in genes such as hMSH2 and hMLH1, which encode components of a DNA mismatch repair system. The MSH2 genomic locus has been cloned and shown to cover approximately 73 kb of genomic DNA and to contain 16 exons. The sequence of all the intron-exon junctions has been determined...

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Source

Identifiers

PMID: 7713503
DOI: 10.1006/geno.1994.1661

Genes

MSH2

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations.PMID 7713503Read ↗

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Molecular characterization of the spectrum of genomic deletions in the mismatch repair genes <i>MSH2</i>, <i>MLH1</i>, <i>MSH6,</i> and <i>PMS2</i> responsible for hereditary nonpolyposis colorectal cancer (HNPCC)Semantic proximity Read ↗

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer.Semantic proximity Read ↗

A 10‐Mb paracentric inversion of chromosome arm 2p inactivates <i>MSH2</i> and is responsible for hereditary nonpolyposis colorectal cancer in a North‐American kindredSemantic proximity Read ↗

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