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Article

Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.

Molecular and cellular biology - 1 May 1992

Watson A J, Weir-Brown K I, Bannister R M, Chu F F, Reisz-Porszasz S, Fujii-Kuriyama Y, Sogawa K, Hankinson O

Abstract excerpt

A dominant mutant of Hepa-1 cells, c31, expresses a repressor that prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-dependent stimulation of Cyp1a1 transcription. The repressor acts via the xenobiotic-responsive elements (XREs), which are the DNA-binding sites for the aryl hydrocarbon (Ah) receptor-TCDD complex during transcriptional activation of the gene. High-salt nuclear extracts prepared from c31 cells...

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Identifiers

PMID: 1314949
DOI: 10.1128/mcb.12.5.2115-2123.1992
PMCID: PMC364383

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