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Article

A facile method for somatic, lifelong manipulation of multiple genes in the mouse liver

7 Feb 2008

Abstract excerpt

UNLABELLED: Current techniques for the alteration of gene expression in the liver have a number of limitations, including the lack of stable somatic gene transfer and the technical challenges of germline transgenesis. Rapid and stable genetic engineering of the liver would allow systematic, in vivo testing of contributions by many genes to disease. After fumaryl acetoacetate hydrolase (Fah) gene transfer to...

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PMID: 18435462
DOI: 10.1002/hep.22195

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