Article
Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes.
Cell - 1 Jun 1990
Ruppert S, Boshart M, Bosch F X, Schmid W, Fournier R E, Schütz G
Abstract excerpt
Mice homozygous for deletions around the albino locus fail to activate expression of a set of neonatal liver functions and die shortly after birth. This phenotype is thought to result from the loss of a positive transacting factor, denoted alf, in deletion homozygotes. Using differential cDNA screening, we isolated and characterized genes whose cell type-specific transcription is affected by alf and found as a...
Topics
- Animals
- Blotting, Northern
- Chromosome Deletion
- Cloning, Molecular
- Gene Expression Regulation
- Kidney
- Liver
- Mice
- Mice, Mutant Strains
- Mutation
- Organ Specificity