Article
Ras pathway activation in malignant mesothelioma.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2007
Patel Manish R, Jacobson Blake A, De Arpita, Frizelle Sandra P, Janne Pasi, Thumma Saritha C, Whitson Brian A, Farassati Faris, Kratzke Robert A
Abstract excerpt
INTRODUCTION: Mutations in Ras family genes are rare in malignant mesothelioma. The role of activation of the Ras signaling pathway in the pathogenesis of mesothelioma is not clear. METHODS: We studied the activation status of the Ras pathway and the status of other Ras-associated kinases in a panel of human mesothelioma cell lines. In addition, we tested the effect of inhibition of several kinase pathways on...
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