Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.

25 Oct 1994

Abstract excerpt

The most frequent DNA adduct made by the anticancer drug cisplatin, the 1,2-intrastrand d(GpG) cross-link, as well as the minor 1,3-intrastrand d(GpTpG) adduct, were both repaired by an in vitro human excision repair system. Fragments of 27-29 nt containing the platinum damage were excised. The high mobility group (HMG)-domain proteins HMG1 and human mitochondrial transcription factor specifically inhibited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Advanced biosensing and bioanalysis techniques
Share to HIV/AIDS drug development and treatment
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7937961
DOI: 10.1073/pnas.91.22.10394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision nuclease.PMID 7937961Read ↗

Recognition and repair of DNA-cisplatin adducts.Semantic proximity Read ↗

Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivitySemantic proximity Read ↗

HMGB1 assists in overcoming cisplatin resistance in chemoresistant human ovarian cancer cellsSemantic proximity Read ↗

Interaction of FACT, SSRP1, and the High Mobility Group (HMG) Domain of SSRP1 with DNA Damaged by the Anticancer Drug CisplatinSemantic proximity Read ↗

Targeting the High-Mobility Group Box 3 Protein Sensitizes Chemoresistant Ovarian Cancer Cells to CisplatinSemantic proximity Read ↗

Association of HMGB1 and HMGB2 genetic polymorphisms with lung cancer chemotherapy response.Semantic proximity Read ↗

Purification of nuclear proteins that bind to cisplatin-damaged DNA. Identity with high mobility group proteins 1 and 2.Semantic proximity Read ↗

Effect of DNA Polymerases and High Mobility Group Protein 1 on the Carrier Ligand Specificity for Translesion Synthesis past Platinum−DNA AdductsSemantic proximity Read ↗

Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adductsSemantic proximity Read ↗

Enhanced binding of the TATA-binding protein to TATA boxes containing flanking cisplatin 1,2-cross-links.Semantic proximity Read ↗

DNA Repair capacity and cisplatin sensitivity of human testis tumour cellsSemantic proximity Read ↗

Inhibition of nucleotide excision repair by high mobility group protein HMGA1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.