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Article

Recognition and repair of DNA-cisplatin adducts.

30 Sept 2002

Abstract excerpt

Anticancer activity of cisplatin (cis-diamminedichloroplatinum) is believed to result from its interaction with DNA. The drug reacts with nucleophilic sites in DNA forming monoadducts as well as intra- and interstrand crosslinks. DNA-cisplatin adducts are specifically recognized by several proteins. They can be divided into two classes. One constitutes proteins which recognize DNA damage as an initial step of the...

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PMID: 12422229
DOI: 10.18388/abp.2002_3768

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