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Article

DNA Repair capacity and cisplatin sensitivity of human testis tumour cells

4 Mar 1997

Abstract excerpt

Metastatic testicular germ cell tumours can be cured using cisplatin-based combination chemotherapy. To investigate the role of DNA repair in cisplatin sensitivity, we measured the formation and removal of cisplatin adducts in the whole genome and in specific genomic regions in 3 testis and 3 bladder cancer cell lines. Following a 1 hr exposure to 50 microM cisplatin, the mean level of DNA platination was lower...

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PMID: 9052754
DOI: 10.1002/(sici)1097-0215(19970304)70:5<551::aid-ijc10>3.0.co;2-g

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Source receipt: pubmed, retrieved 7 Sept 2026.

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