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Article

Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

Nature - 6 Oct 1994

McGuire W, Hill A V, Allsopp C E, Greenwood B M, Kwiatkowski D

Abstract excerpt

Tumour-necrosis factor-alpha (TNF-alpha) is believed to have an important role in the pathogenesis of severe infectious disease and fatal cerebral malaria is associated with high circulating levels of this cytokine. In a large case-control study in Gambian children we find that homozygotes for the TNF2 allele, a variant of the TNF-alpha gene promoter region, have a relative risk of 7 for death or severe...

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PMID: 7935762
DOI: 10.1038/371508a0

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.PMID 7935762Read ↗

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Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.Semantic proximity Read ↗

IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.Semantic proximity Read ↗

Tumour necrosis factor alpha promoter polymorphism, TNF-238 is associated with severe clinical outcome of falciparum malaria in Ibadan southwest Nigeria.Semantic proximity Read ↗

The cytokine TNF-alpha. Genetics and suitability for prenatal risks assessment.Semantic proximity Read ↗

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.Semantic proximity Read ↗

TNF-α promoter variant (G-308A) is associated with susceptibility to P. falciparum infection and severe malaria: a meta-analysis and trial sequential analysis.Semantic proximity Read ↗

Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.Semantic proximity Read ↗

A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility.Semantic proximity Read ↗

[Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease].Semantic proximity Read ↗

Plasma interleukin-10:Tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications.Semantic proximity Read ↗

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