Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

doi:10.1038/371508a0

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Article

Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.

Nature - 6 Oct 1994

McGuire W, Hill A V, Allsopp C E, Greenwood B M, Kwiatkowski D

Abstract excerpt

Tumour-necrosis factor-alpha (TNF-alpha) is believed to have an important role in the pathogenesis of severe infectious disease and fatal cerebral malaria is associated with high circulating levels of this cytokine. In a large case-control study in Gambian children we find that homozygotes for th...

Topics

Alleles
Animals
Base Sequence
Case-Control Studies
Child
Child, Preschool
DNA Primers
Gambia
Gene Frequency
Genetic Predisposition to Disease
HLA Antigens
Histocompatibility Testing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Infant

Malaria, Cerebral

Molecular Sequence Data

Plasmodium falciparum

Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 7935762
DOI: 10.1038/371508a0

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7935762-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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