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Article

Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.

The Journal of infectious diseases - 1 Oct 1996

Nadel S, Newport M J, Booy R, Levin M

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the pathophysiology of sepsis. Levels of TNF-alpha are directly correlated with severity in meningococcal disease (MD). A polymorphism in the promoter region of the TNF-alpha gene is associated with differences in the secretion of TNF-alpha. The TNF2 allele is associated with higher constitutive and inducible levels of TNF-alpha secretion than is the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8843235
DOI: 10.1093/infdis/174.4.878

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.PMID 8843235Read ↗

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[Tumor necrosis factor alpha genetic polymorphism as a risk factor in disease].Semantic proximity Read ↗

Association between tumor necrosis factor-alpha promoter -308 A/G polymorphism and susceptibility to sepsis and sepsis mortality: a systematic review and meta-analysis.Semantic proximity Read ↗

Tumor necrosis factor-alpha promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX.Semantic proximity Read ↗

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