Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.

doi:10.1093/infdis/174.4.878

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Article

Variation in the tumor necrosis factor-alpha gene promoter region may be associated with death from meningococcal disease.

The Journal of infectious diseases - 1 Oct 1996

Nadel S, Newport M J, Booy R, Levin M

Abstract excerpt

Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the pathophysiology of sepsis. Levels of TNF-alpha are directly correlated with severity in meningococcal disease (MD). A polymorphism in the promoter region of the TNF-alpha gene is associated with differences in the secretion of TN...

Topics

Alleles
Child
Humans
Meningococcal Infections
Promoter Regions, Genetic
Tumor Necrosis Factor-alpha

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