Article

The host inflammatory response in the pathogenesis of malaria in Gambian children

1998-01-01

Abstract excerpt

The host inflammatory response may be involved in the pathogenesis of severe malaria. High plasma levels of pro-inflammatory cytokines, notably tumour necrosis factor (TNP), are found in African children with cerebral malaria. Experimental evidence also implicates TNF in the pathogenic process of severe malarial anaemia. We have examined the association of polymorphisms in the TNF gene promoter region with severe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a27f2e97-1b4f-5b72-a78d-4d5115a5da7c
DOI: 10.5525/gla.thesis.71350

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The host inflammatory response in the pathogenesis of malaria in Gambian childrenDOI 10.5525/gla.thesis.71350Read

Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.Semantic proximity Read

Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.Semantic proximity Read

Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles.Semantic proximity Read

Tumour necrosis factor alpha promoter polymorphism, TNF-238 is associated with severe clinical outcome of falciparum malaria in Ibadan southwest Nigeria.Semantic proximity Read

IFNGR1 gene promoter polymorphisms and susceptibility to cerebral malaria.Semantic proximity Read

Tumor necrosis factor-α (TNF-α) -308G >a promoter polymorphism (rs1800629) promotes Asians in susceptibility to Plasmodium falciparum severe malaria: A meta-analysis.Semantic proximity Read

Alleles 308A and 238A in the tumor necrosis factor alpha gene promoter do not increase the risk of severe malaria in children with Plasmodium falciparum infection in Mali.Semantic proximity Read

Plasma interleukin-10:Tumor necrosis factor (TNF)-alpha ratio is associated with TNF promoter variants and predicts malarial complications.Semantic proximity Read

Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study.Semantic proximity Read

Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.Semantic proximity Read

Identifying host-pathogen interactions which cause severe malariaSemantic proximity Read

Role of IL-1β, IL-6 and TNF-α cytokines and TNF-α promoter variability in Plasmodium vivax infection during pregnancy in endemic population of Jharkhand, India.Semantic proximity Read