A polymorphic residue in the amino terminal alpha 1 hemi-domain of the mouse Ld class I molecule affects its assembly and surface expression.

doi:10.1016/0161-5890(94)90031-0

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Article

A polymorphic residue in the amino terminal alpha 1 hemi-domain of the mouse Ld class I molecule affects its assembly and surface expression.

Molecular immunology - 1 Oct 1994

Talken B L, Peterson K, Harrison L G, Lee D R

Abstract excerpt

In comparison to Dd and most other mouse major histocompatibility complex class I molecules, the Ld molecule is poorly expressed on the cell surface, has a lower affinity for beta 2-microglobulin and is trafficked more slowly to the cell surface. Previous studies using Ld-Dd exon-shuffled constru...

Topics

Animals
Base Sequence
Gene Expression
Histocompatibility Antigens
Mice
Molecular Sequence Data
Mutation
Point Mutation
Precipitin Tests
Structure-Activity Relationship
beta 2-Microglobulin

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