Actin and fimbrin are required for the internalization step of endocytosis in yeast.

doi:10.1002/j.1460-2075.1993.tb05947.x

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Article

Actin and fimbrin are required for the internalization step of endocytosis in yeast.

The EMBO journal - 1 Jul 1993

Kübler E, Riezman H

Abstract excerpt

In Saccharomyces cerevisiae, alpha-factor is internalized by receptor-mediated endocytosis and transported via vesicular intermediates to the vacuole where the pheromone is degraded. Using beta-tubulin and actin mutant strains, we showed that actin plays a direct role in receptor-mediated internalization of alpha-factor, but is not necessary for transport from the endocytic intermediates to the vacuole....

Topics

Actins
Biological Transport
Carrier Proteins
Endocytosis
Mating Factor
Membrane Glycoproteins
Microfilament Proteins
Mutation
Organelles
Peptides
Saccharomyces cerevisiae

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Identifiers

PMID: 8335001
DOI: 10.1002/j.1460-2075.1993.tb05947.x
PMCID: PMC413538

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