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Article

Recombinant influenza A H3N2 viruses with mutations of HA transmembrane cysteines exhibited altered virological characteristics.

Virus genes - 1 Apr 2014

Zhou Jianqiang, Xu Shun, Ma Jun, Lei Wen, Liu Kang, Liu Qiliang, Ren Yida, Xue Chunyi, Cao Yongchang

Abstract excerpt

Influenza A H3N2 virus as the cause of 1968 pandemic has since been circulating in human and swine. Our earlier study has shown that mutations of one or two cysteines in the transmembrane domain of H3 hemagglutinin (HA) affected the thermal stability and fusion activity of recombinant HA proteins. Here, we report the successful generation of three recombinant H3N2 mutant viruses (C540S, C544L, and 2C/SL) with...

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PMID: 24272698
DOI: 10.1007/s11262-013-1011-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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