Article
Phenotype/genotype relationships for the cytochrome P450 enzyme CYP2D6 in rheumatoid arthritis: influence of drug therapy and disease activity.
The Journal of rheumatology - 1 Jun 1994
Beyeler C, Daly A K, Armstrong M, Astbury C, Bird H A, Idle J R
Abstract excerpt
OBJECTIVE: To determine whether particular genotypes for the cytochrome P450 enzyme CYP2D6, a polymorphic enzyme, are associated with susceptibility to rheumatoid arthritis (RA) and whether CYP2D6 enzyme activity is altered as a result of the disease or its treatment. METHODS: CYP2D6 genotypes an...
Topics
- Adult
- Aged
- Alleles
- Anti-Inflammatory Agents
- Arthritis, Rheumatoid
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Dextropropoxyphene
- Disease Susceptibility
- Female
- Genotype
- Humans
- Hydroxylation
- Male
- Middle Aged
- Mixed Function Oxygenases
- Phenotype