Article
C/EBP beta regulation of the tumor necrosis factor alpha gene.
The Journal of clinical investigation - 1 Oct 1994
Pope R M, Leutz A, Ness S A
Abstract excerpt
Activated macrophages contribute to chronic inflammation by the secretion of cytokines and proteinases. Tumor necrosis factor alpha (TNF alpha) is particularly important in this process because of its ability to regulate other inflammatory mediators in an autocrine and paracrine fashion. The mech...
Topics
- Base Sequence
- Binding Sites
- CCAAT-Enhancer-Binding Proteins
- Cell Line
- DNA
- DNA-Binding Proteins
- Humans
- Molecular Sequence Data
- Monocytes
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Recombinant Fusion Proteins
- T-Lymphocytes
- Tetradecanoylphorbol Acetate
- Transcription Factors
- Transcriptional Activation
- Transfection