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Article

Post-transcriptional regulation of pro-inflammatory gene expression.

1 Jan 2000

Abstract excerpt

The cytokine tumour necrosis factor (TNF)alpha is a vital mediator of the innate immune response, and a pleiotropic regulator of cellular function. Its involvement in rheumatoid arthritis is illustrated by the clinical benefits of TNF alpha blockade. Post-transcriptional regulation (the control of mRNA stability and translation) appears to play a critical role in the regulation of TNF alpha expression by mitogen...

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PMID: 11094425
DOI: 10.1186/ar83

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