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Article

NF-kappaB--a potential therapeutic target for inhibition of human cytomegalovirus (re)activation?

Biological chemistry - 1 Oct 2002

Prösch Susanna, Wuttke Regine, Krüger Detlev H, Volk Hans-Dieter

Abstract excerpt

From clinical studies the proinflammatory cytokine TNFalpha was proposed to play a key role in human cytomegalovirus (HCMV) reactivation from latency. In vitro experiments confirmed that TNFalpha stimulates the activity of the HCMV IE1/2 enhancer/promoter, which controls immediate early protein IE1 and IE2 gene expression via activation of the transcription factor NF-kappaB and its binding to putative binding...

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Share to Consensus Sequence
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Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to HL-60 Cells

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Source

Identifiers

PMID: 12452437
DOI: 10.1515/BC.2002.181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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