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Article

Cooperation between PU.1 and CAAT/enhancer-binding protein beta is necessary to induce the expression of the MD-2 gene.

The Journal of biological chemistry - 25 Sept 2009

Tissières Pierre, Araud Tanguy, Ochoda Agnieszka, Drifte Geneviève, Dunn-Siegrist Irène, Pugin Jérôme

Abstract excerpt

Myeloid differentiation factor 2 (MD-2) binds Gram-negative bacterial lipopolysaccharide with high affinity and is essential for Toll-like receptor 4-dependent signal transduction. MD-2 has recently been recognized as a type II acute phase protein. Plasma concentrations of the soluble form of MD-...

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Identifiers

PMID: 19632992
DOI: 10.1074/jbc.M109.042580
PMCID: PMC2785314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19632992-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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