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Article

Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.

The Journal of clinical investigation - 1 Oct 1994

West D B, Goudey-Lefevre J, York B, Truett G E

Abstract excerpt

Loci linked to sensitivity to dietary obesity were identified by Quantitative Trait Locus (QTL) analysis of two mapping populations derived from a cross between AKR/J and SWR/J mice. AKR/J mice are sensitive to dietary obesity when fed a high fat diet while SWR/J mice are resistant. Intercrosses between these strains segregate the phenotype of sensitivity to dietary obesity. Using an F2 mapping population of 931...

Topics

Adipose Tissue
Animals
Chromosome Mapping
Chromosomes
Crosses, Genetic
Diet
Female
Genetic Linkage
Genetic Markers
Genotype
Male
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred AKR

Mice, Inbred Strains

Obesity

Polymorphism, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 7929816
DOI: 10.1172/JCI117477
PMCID: PMC295268

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7929816-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model.PMID 7929816Read ↗

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