Characterization of epistasis influencing complex spontaneous obesity in the BSB model.

doi:10.1534/genetics.167.1.399

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Article

Characterization of epistasis influencing complex spontaneous obesity in the BSB model.

Genetics - 1 May 2004

Yi Nengjun, Diament Adam, Chiu Sally, Kim Kyoungmi, Allison David B, Fisler Janis S, Warden Craig H

Abstract excerpt

There is growing awareness that complex interactions among multiple genes and environmental factors play an important role in controlling obesity traits. The BSB mouse, which is produced by the backcross of (lean C57BL/6J x lean Mus spretus) x C57BL/6J, provides an excellent model of epistatic obesity. To evaluate potential epistatic interactions among six chromosomal regions previously determined to influence...

Topics

Adipose Tissue
Animals
Bayes Theorem
Body Constitution
Body Weight
Cholesterol
Chromosome Mapping
Crosses, Genetic
Disease Models, Animal
Epistasis, Genetic
Genetic Markers
Genotype
Humans
Mice

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Models, Genetic

Models, Statistical

Obesity

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Identifiers

PMID: 15166164
DOI: 10.1534/genetics.167.1.399
PMCID: PMC1470871

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