Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei x C57BL/6J F2 intercross.

doi:10.1007/s003359900204

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Article

Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei x C57BL/6J F2 intercross.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 1996

York B, Lei K, West D B

Abstract excerpt

Details of a new model of diet-dependent polygenic obesity are presented. CAST/Ei (Mus m. castaneus) mice remain lean after 12 weeks on a high-fat (32 kcal% fat) diet, while C57BL/6J mice become obese. The genes responsible for the obesity segregate in an F2 population derived from an intercross...

Topics

Adipose Tissue
Analysis of Variance
Animals
Body Weight
Chromosome Mapping
Crosses, Genetic
Dietary Fats
Female
Genetic Linkage
Genetic Markers
Genotype
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred C57BL

Mice, Inbred Strains

Multigene Family

Obesity

Source

Open in PubMed

Identifiers

PMID: 8703121
DOI: 10.1007/s003359900204

Genes

CAST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8703121-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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