Article
Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
The New England journal of medicine - 11 Jun 2009
Hirschfield Gideon M, Liu Xiangdong, Xu Chun, Lu Yue, Xie Gang, Lu Yan, Gu Xiangjun, Walker Erin J, Jing Kaiyan, Juran Brian D, Mason Andrew L, Myers Robert P, Peltekian Kevork M, Ghent Cameron N, Coltescu Catalina, Atkinson Elizabeth J, Heathcote E Jenny, Lazaridis Konstantinos N, Amos Christopher I, Siminovitch Katherine A
Abstract excerpt
BACKGROUND: Primary biliary cirrhosis is a chronic granulomatous cholangitis, characteristically associated with antimitochondrial antibodies. Twin and family aggregation data suggest that there is a significant genetic predisposition to primary biliary cirrhosis, but the susceptibility loci are unknown. METHODS: To identify genetic loci conferring a risk for primary biliary cirrhosis, we carried out a genomewide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.