Article
Genetic and familial considerations of primary biliary cirrhosis.
The American journal of gastroenterology - 1 Jan 2001
Tanaka A, Borchers A T, Ishibashi H, Ansari A A, Keen C L, Gershwin M E
Abstract excerpt
The genetic basis of human autoimmune diseases is receiving increasing attention. Primary biliary cirrhosis (PBC) is a model autoimmune disease reflective of other organ-specific autoimmune pathology. PBC is an enigmatic autoimmune disease that predominantly affects women and leads to destruction of intrahepatic bile ducts. The serological hallmark of this disease is characterized by antimitochondrial antibodies...
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