Article
Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.
Hepatology (Baltimore, Md.) - 1 Dec 1992
Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R
Abstract excerpt
In studies to date seeking associations between human leukocyte antigens (HLA) and primary biliary cirrhosis, no class I association but several different class II associations have been described. The aims of this study were to reassess the DR associations in primary biliary cirrhosis and to exa...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Base Sequence
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Disease Susceptibility
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Haplotypes
- Humans
- Liver Cirrhosis, Biliary
- Major Histocompatibility Complex