Article
Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype.
Hepatology (Baltimore, Md.) - 1 Dec 1992
Underhill J, Donaldson P, Bray G, Doherty D, Portmann B, Williams R
Abstract excerpt
In studies to date seeking associations between human leukocyte antigens (HLA) and primary biliary cirrhosis, no class I association but several different class II associations have been described. The aims of this study were to reassess the DR associations in primary biliary cirrhosis and to examine for the first time the role of DQB. DRB genotypes were determined on standard Taq1 restriction-fragment-length...
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