Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome.

Genes & development - 1 May 1994

Madhani H D, Guthrie C

Abstract excerpt

Putative components of the spliceosomal active site include a bulged helix between U2 and U6 snRNAs (U2-U6 helix I) and the adjacent ACAGAG hexanucleotide in U6. We have developed an in vivo, bimolecular randomization-selection method to functionally dissect these elements. Although a portion of U2-U6 helix I resembles the G-binding site of group I introns, the data are inconsistent with an analogous functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Mutation

Share to Phenotype

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 7926788
DOI: 10.1101/gad.8.9.1071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome.PMID 7926788Read ↗

Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Semantic proximity Read ↗

Mutations in U6 snRNA that alter splice site specificity: implications for the active site.Semantic proximity Read ↗

A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.Semantic proximity Read ↗

U1 snRNA promotes the selection of nearby 5' splice sites by U6 snRNA in mammalian cells.Semantic proximity Read ↗

Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.Semantic proximity Read ↗

Multiple functions for the invariant AGC triad of U6 snRNA.Semantic proximity Read ↗

Interactions of the yeast U6 RNA with the pre-mRNA branch site.Semantic proximity Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

The phylogenetically invariant ACAGAGA and AGC sequences of U6 small nuclear RNA are more tolerant of mutation in human cells than in Saccharomyces cerevisiae.Semantic proximity Read ↗

Multiple roles for U6 snRNA in the splicing pathway.Semantic proximity Read ↗

Involvement of U6 snRNA in 5' splice site selection.Semantic proximity Read ↗

Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.