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Article

c-Myb regulates the proliferation of immature thymocytes following beta-selection.

The EMBO journal - 15 Nov 2000

Pearson R, Weston K

Abstract excerpt

Transgenic mice expressing a T-cell-specific dominant interfering allele (MEnT) of the c-Myb transcription factor have a pronounced block in CD4(-)CD8(-) (DN) development. In this study we show that differentiation of DN MEnT thymocytes is blocked due to the failure of cells to enter the cell cycle following beta-selection, the process by which productive rearrangement of the T-cell receptor (TCR) beta-chain...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11080157
DOI: 10.1093/emboj/19.22.6112
PMCID: PMC305827

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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