Article
Monokine antagonism is reduced in patients with IDDM.
Diabetes - 1 Oct 1994
Mandrup-Poulsen T, Pociot F, Mølvig J, Shapiro L, Nilsson P, Emdal T, Røder M, Kjems L L, Dinarello C A, Nerup J
Abstract excerpt
Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) have been implicated as immune effector molecules in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Recently, an increased frequency of the A1/A1 genotype of an IL-1 receptor antagonist (IL-1Ra) gene polymorphism wa...
Topics
- Adult
- Base Sequence
- Blood Glucose
- DNA Primers
- Diabetes Mellitus, Type 1
- Genotype
- Humans
- Interleukin 1 Receptor Antagonist Protein
- Leukocyte Count
- Male
- Molecular Sequence Data
- Monokines
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Radioimmunoassay
- Receptors, Tumor Necrosis Factor
- Reference Values
- Sialoglycoproteins