Article
Monokine antagonism is reduced in patients with IDDM.
Diabetes - 1 Oct 1994
Mandrup-Poulsen T, Pociot F, Mølvig J, Shapiro L, Nilsson P, Emdal T, Røder M, Kjems L L, Dinarello C A, Nerup J
Abstract excerpt
Interleukin-1 (IL-1) and tumor necrosis factor alpha (TNF-alpha) have been implicated as immune effector molecules in the pathogenesis of insulin-dependent diabetes mellitus (IDDM). Recently, an increased frequency of the A1/A1 genotype of an IL-1 receptor antagonist (IL-1Ra) gene polymorphism was observed in patients with IDDM. Therefore, we investigated plasma IL-1Ra and soluble TNF p55 receptor (TNFsRp55)...
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