The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity.

doi:10.1093/carcin/15.9.1895

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Article

The role of two conserved amino acids, glutamine 90 and asparagine 137, in O6-methylguanine-DNA methyltransferase stability, activity and substrate specificity.

Carcinogenesis - 1 Sept 1994

Pieper R O, Morgan S E, Kelley M R

Abstract excerpt

To assess the possibility that two conserved amino acids (glutamine 90 and asparagine 137) in O6-methylguanine-DNA methyltransferase (MGMT) are involved in protein-substrate contact and/or discrimination between favored and non-favored substrates, families of proteins mutant at these two sites we...

Topics

Asparagine
Binding Sites
DNA
DNA Repair
Enzyme Stability
Glutamine
Guanine
Methyltransferases
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Substrate Specificity

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