Structural and functional roles of cysteine 90 and cysteine 240 in S-adenosylmethionine synthetase.

doi:10.1074/jbc.270.31.18484

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Article

Structural and functional roles of cysteine 90 and cysteine 240 in S-adenosylmethionine synthetase.

The Journal of biological chemistry - 4 Aug 1995

Reczkowski R S, Markham G D

Abstract excerpt

Site-specific mutagenesis was performed on the structural gene for Escherichia coli S-adenosylmethionine (AdoMet) synthetase to introduce mutations at cysteines 90 and 240, residues previously implicated by chemical modification studies to be catalytically and/or structurally important. The AdoMe...

Topics

Adenosine Triphosphate
Cysteine
Electrophoresis, Polyacrylamide Gel
Enzyme Stability
Escherichia coli
Kinetics
Methionine
Methionine Adenosyltransferase
Molecular Weight
Mutagenesis, Site-Directed
Mutation
Protein Conformation
Structure-Activity Relationship

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Identifiers

PMID: 7629176
DOI: 10.1074/jbc.270.31.18484

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7629176-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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