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Article

Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase.

Carcinogenesis - 1 May 2002

Xu-Welliver Meng, Pegg Anthony E

Abstract excerpt

O(6)-Alkylguanine-DNA alkyltransferase (AGT) is a DNA repair protein that removes alkyl groups from DNA by transferring them to an internal Cys-145 residue. As the S-alkylcysteine is not converted back to cysteine, the protein can only act once and the resulting alkylated AGT molecule is rapidly degraded. The mechanism underlying the disappearance of the alkylated AGT has been studied in vivo in CHO cells and in...

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Source

Identifiers

PMID: 12016156
DOI: 10.1093/carcin/23.5.823

Genes

AGT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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