Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alteration of lysine 178 in the hinge region of the Escherichia coli ada protein interferes with activation of ada, but not alkA, transcription.

Journal of bacteriology - 1 Mar 1995

Saget B M, Shevell D E, Walker G C

Abstract excerpt

The ada gene of Escherichia coli K-12 encodes the 39-kDa Ada protein, which consists of two domains joined by a hinge region that is sensitive to proteolytic cleavage in vitro. The amino-terminal domain has a DNA methyltransferase activity that repairs the S-diastereoisomer of methylphosphotriesters while the carboxyl-terminal domain has a DNA methyltransferase activity that repairs O6-methylguanine and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Base Sequence
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli Proteins

Share to Gene Expression Regulation, Bacterial

Share to Molecular Sequence Data

Share to Mutation

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 7868601
DOI: 10.1128/jb.177.5.1268-1274.1995
PMCID: PMC176733

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alteration of lysine 178 in the hinge region of the Escherichia coli ada protein interferes with activation of ada, but not alkA, transcription.PMID 7868601Read ↗

Molecular analysis of Bacillus subtilis ada mutants deficient in the adaptive response to simple alkylating agents.Semantic proximity Read ↗

Regulatory elements for expression of the alkA gene in response to alkylating agents.Semantic proximity Read ↗

Trapping distinct structural states of a protein/DNA interaction through disulfide crosslinking.Semantic proximity Read ↗

Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine.Semantic proximity Read ↗

ATPase-defective derivatives of Escherichia coli DnaK that behave differently with respect to ATP-induced conformational change and peptide release.Semantic proximity Read ↗

The Cro-like Apl repressor of coliphage 186 is required for prophage excision and binds near the phage attachment site.Semantic proximity Read ↗

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.Semantic proximity Read ↗

Inhibition of O6-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli.Semantic proximity Read ↗

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site.Semantic proximity Read ↗

Reaction of LexA repressor with diisopropyl fluorophosphate. A test of the serine protease model.Semantic proximity Read ↗

Threonine 435 of Escherichia coli DnaA protein confers sequence-specific DNA binding activity.Semantic proximity Read ↗

The A184V missense mutation of the dnaA5 and dnaA46 alleles confers a defect in ATP binding and thermolability in initiation of Escherichia coli DNA replication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.