Article
Differential effects on cell killing in metallothionein overexpressing CHO mutant cell lines.
Carcinogenesis - 1 Nov 1990
Lohrer H, Robson T, Grindley H, Foster S, Hall A
Abstract excerpt
An increased level of metallothionein (MT) within the cytosol has been associated with the development of resistance to the cytotoxic effects of alkylating agents, but the mechanism of this effect is unclear. To verify the possible role of MT as a direct scavenger of alkylating agents we transfec...
Topics
- Animals
- Cell Line
- Cricetinae
- Drug Resistance
- Gene Amplification
- Metallothionein
- Methylnitronitrosoguanidine
- Mutation
- Plasmids
- Transfection