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Article

Differential effects on cell killing in metallothionein overexpressing CHO mutant cell lines.

Carcinogenesis - 1 Nov 1990

Lohrer H, Robson T, Grindley H, Foster S, Hall A

Abstract excerpt

An increased level of metallothionein (MT) within the cytosol has been associated with the development of resistance to the cytotoxic effects of alkylating agents, but the mechanism of this effect is unclear. To verify the possible role of MT as a direct scavenger of alkylating agents we transfected two alkylating agent sensitive CHO mutant cell lines, methyl methanesulphate-1 and -2 (MMS-1 and MMS-2), with the...

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Source

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PMID: 2225325
DOI: 10.1093/carcin/11.11.1937

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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