Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New mouse somatic cell mutants resistant to cadmium affected in the expression of their metallothionein genes.

Journal of cellular physiology - 1 Feb 1990

Chopra A, Thibodeau J, Tam Y C, Marengo C, Mbikay M, Thirion J P

Abstract excerpt

Fluctuation tests à la Luria and Delbruck were performed with mouse LMTK cells, and the results indicate that the appearance of variants resistant to cadmium is due to random spontaneous mutations and not to epigenetic events. The rate of spontaneous mutations leading to cadmium resistance was ca...

Topics

Animals
Cadmium
Cell Line
Clone Cells
DNA
Drug Resistance
Gene Amplification
Gene Expression Regulation
Metallothionein
Mice
Mutation
Nucleic Acid Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Messenger

Source

Identifiers

PMID: 2303527
DOI: 10.1002/jcp.1041420214

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2303527-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New mouse somatic cell mutants resistant to cadmium affected in the expression of their metallothionein genes.PMID 2303527Read ↗

Selection of mouse cells with amplified metallothionein genes retaining their glucocorticoid inducibility.Semantic proximity Read ↗

Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium.Semantic proximity Read ↗

Analysis of the role of 5' regulatory mutations in the activation of quiescent metallothionein genes after carcinogen treatment.Semantic proximity Read ↗

A role for metallothionein and zinc in spontaneous mutagenesis.Semantic proximity Read ↗

Gene expression profiling in wild-type and metallothionein mutant fibroblast cell lines.Semantic proximity Read ↗

Targeting and germ-line transmission of a null mutation at the metallothionein I and II loci in mouse.Semantic proximity Read ↗

Genetic control of cadmium tolerance in Drosophila melanogaster.Semantic proximity Read ↗

Lead and mercury mutagenesis: type of mutation dependent upon metal concentration.Semantic proximity Read ↗

Cloning genes whose levels of expression are altered by metals: implications for human health research.Semantic proximity Read ↗

The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies.Semantic proximity Read ↗

Mutagenicity of mercury chloride and mechanisms of cellular defence: the role of metal-binding proteins.Semantic proximity Read ↗

Cadmium partitioning in trangenic tobacco plants expressing a mammalian metallothionein geneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.