Article
Imprinting of human H19: allele-specific CpG methylation, loss of the active allele in Wilms tumor, and potential for somatic allele switching.
American journal of human genetics - 1 Jul 1993
Zhang Y, Shields T, Crenshaw T, Hao Y, Moulton T, Tycko B
Abstract excerpt
Genomic imprinting and monoallelic gene expression appear to play a role in human genetic disease and tumorigenesis. The human H19 gene, at chromosome 11p15, has previously been shown to be monoallelically expressed. Since CpG methylation has been implicated in imprinting, we analyzed methylation of H19 DNA. In fetal and adult organs the transcriptionally silent H19 allele was extensively hypermethylated through...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.