Article
A nucleolar protein, <i>H19</i> opposite tumor suppressor ( <i>HOTS</i> ), is a tumor growth inhibitor encoded by a human imprinted <i>H19</i> antisense transcript
21 Sept 2011
Abstract excerpt
The H19 gene, which localizes within a chromosomal region on human chromosome 11p15 that is commonly lost in Wilms tumor (WT), encodes an imprinted untranslated RNA. However, the biological significance of the H19 noncoding transcript remains unresolved because replacement of the RNA transcript with a neocassette has no obvious phenotypic effect. Here we show that the human H19 locus also encodes a maternally...
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