Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.

doi:10.1038/ng0794-370

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Article

Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.

Nature genetics - 1 Jul 1994

Lahti J M, Valentine M, Xiang J, Jones B, Amann J, Grenet J, Richmond G, Look A T, Kidd V J

Abstract excerpt

p58cdc2L1, a protein kinase implicated in apoptotic signaling, is one of eight separate kinases encoded by three tandemly duplicated and linked genes, which we have termed PITSLRE A, B and C. One allele of this complex on chromosome 1 was either deleted or translocated in each of 18 neuroblastoma...

Topics

Alleles
Child
Child, Preschool
Chromosomes, Human, Pair 1
Cyclin-Dependent Kinases
Genes
Genes, Tumor Suppressor
Humans
In Situ Hybridization, Fluorescence
Infant
Monosomy
Multigene Family
Neuroblastoma
Protein Kinases
Protein Serine-Threonine Kinases

Source

Open in PubMed

Identifiers

PMID: 7920654
DOI: 10.1038/ng0794-370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7920654-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repetitive Sequences, Nucleic Acid

Sequence Deletion

Translocation, Genetic