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Article

Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.

Nature genetics - 1 Jul 1994

Lahti J M, Valentine M, Xiang J, Jones B, Amann J, Grenet J, Richmond G, Look A T, Kidd V J

Abstract excerpt

p58cdc2L1, a protein kinase implicated in apoptotic signaling, is one of eight separate kinases encoded by three tandemly duplicated and linked genes, which we have termed PITSLRE A, B and C. One allele of this complex on chromosome 1 was either deleted or translocated in each of 18 neuroblastoma cell lines with cytogenetically apparent 1p alterations. A protein encoded by this locus, PITSLRE gamma 1, was absent...

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Identifiers

PMID: 7920654
DOI: 10.1038/ng0794-370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma.PMID 7920654Read ↗

Abnormalities in the p34cdc2-related PITSLRE protein kinase gene complex (CDC2L) on chromosome band 1p36 in melanoma.Semantic proximity Read ↗

Definition and characterization of a region of 1p36.3 consistently deleted in neuroblastoma.Semantic proximity Read ↗

Identification of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas.Semantic proximity Read ↗

Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms.Semantic proximity Read ↗

Detailed molecular analysis of 1p36 in neuroblastoma.Semantic proximity Read ↗

Gene expression profiling of 1p35-36 genes in neuroblastoma.Semantic proximity Read ↗

Mutations of 1p genes do not consistently abrogate tumor suppressor functions in 1p-intact neuroblastoma.Semantic proximity Read ↗

Comprehensive analysis of chromosome 1p deletions in neuroblastoma.Semantic proximity Read ↗

Reassignment of the EPB4.1 gene to 1p36 and assessment of its involvement in neuroblastomas.Semantic proximity Read ↗

Molecular analysis of the putative tumour-suppressor gene EXTL1 in neuroblastoma patients and cell lines.Semantic proximity Read ↗

RAS-MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma.Semantic proximity Read ↗

Smallest region of overlapping deletion in 1p36 in human neuroblastoma: A 1 Mbp cosmid and PAC contigSemantic proximity Read ↗

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