Article
RAS-MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma.
Cancer research - 1 Nov 2018
Eleveld Thomas F, Schild Linda, Koster Jan, Zwijnenburg Danny A, Alles Lindy K, Ebus Marli E, Volckmann Richard, Tijtgat Godelieve A, van Sluis Peter, Versteeg Rogier, Molenaar Jan J
Abstract excerpt
Mutations affecting the RAS-MAPK pathway frequently occur in relapsed neuroblastoma tumors, which suggests that activation of this pathway is associated with a more aggressive phenotype. To explore this hypothesis, we generated several model systems to define a neuroblastoma RAS-MAPK pathway signature. Activation of this pathway in primary tumors indeed correlated with poor survival and was associated with known...
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