Article
Abnormalities in the p34cdc2-related PITSLRE protein kinase gene complex (CDC2L) on chromosome band 1p36 in melanoma.
Cancer genetics and cytogenetics - 15 Jan 1999
Nelson M A, Ariza M E, Yang J M, Thompson F H, Taetle R, Trent J M, Wymer J, Massey-Brown K, Broome-Powell M, Easton J, Lahti J M, Kidd V J
Abstract excerpt
The two genes encoding the PITSLRE protein kinase isoforms, CDC2L1 and CDC2L2, are localized to human chromosome band 1p36. The PITSLRE protein kinases are a part of the p34cdc2 supergene family. Several protein products of the CDC2L locus may be effector(s) in apoptotic signaling. The larger PIT...
Topics
- Base Sequence
- Chromosomes, Human, Pair 1
- Cyclin-Dependent Kinases
- DNA, Neoplasm
- Humans
- In Situ Hybridization
- Melanoma
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Protein Kinases
- Protein Serine-Threonine Kinases
- Tumor Cells, Cultured