Isoguanosine substitution of conserved adenosines in the hammerhead ribozyme.

doi:10.1021/bi00206a015

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Article

Isoguanosine substitution of conserved adenosines in the hammerhead ribozyme.

Biochemistry - 11 Oct 1994

Ng M M, Benseler F, Tuschl T, Eckstein F

Abstract excerpt

Isoguanosine has been incorporated into a 34-mer hammerhead ribozyme by the solid-phase phosphoramidite method, using an acetamidine base protecting group. The activity of the hammerhead ribozyme when singly mutated to isoguanosine at the adenosine positions 6, 9, and 13 was 1-2-fold less than th...

Topics

2-Aminopurine
Adenosine
Amidines
Base Sequence
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Electrophoresis, Polyacrylamide Gel
Guanosine
Magnetic Resonance Spectroscopy
Molecular Sequence Data
Mutation
Oligodeoxyribonucleotides
RNA, Catalytic
Structure-Activity Relationship
Trypsin Inhibitors

Source

Open in PubMed

Identifiers

PMID: 7918433
DOI: 10.1021/bi00206a015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7918433-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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