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Article

Contrasting roles for symmetrically disposed beta-turns in the folding of a small protein.

Journal of molecular biology - 12 Dec 1997

Gu H, Kim D, Baker D

Abstract excerpt

To investigate the role of turns in protein folding, we have characterized the effects of combinatorial and site-directed mutations in the two beta-turns of peptostreptococcal protein L on folding thermodynamics and kinetics. Sequences of folded variants recovered from combinatorial libraries using a phase display selection method were considerably more variable in the second turn than in the first turn. These...

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PMID: 9417937
DOI: 10.1006/jmbi.1997.1374

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