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Article

The p53 status of cultured human premalignant oral keratinocytes.

British journal of cancer - 1 Oct 1994

Burns J E, Clark L J, Yeudall W A, Mitchell R, Mackenzie K, Chang S E, Parkinson E K

Abstract excerpt

Around 60% of oral squamous cell carcinomas (SCCs) have been shown to harbour p53 mutations, and other studies have demonstrated mutant p53 genes in normal and dysplastic squamous epithelium adjacent to these SCCs. In line with these earlier studies we show here that DOK, a keratinocyte cell line derived from a dysplasia, displays elevated levels of p53 protein and harbours a 12 bp in-frame deletion of the p53...

Topics

Biopsy
Carcinoma, Squamous Cell
Cells, Cultured
Exons
Genes, p53
Head and Neck Neoplasms
Humans
Keratinocytes
Mutation
Papilloma
Papillomaviridae
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precancerous Conditions

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Identifiers

PMID: 7917902
DOI: 10.1038/bjc.1994.356
PMCID: PMC2033430

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7917902-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The p53 status of cultured human premalignant oral keratinocytes.PMID 7917902Read ↗

A high prevalence of p53 mutations in pre-malignant oral erythroplakiaSemantic proximity Read ↗

DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype.Semantic proximity Read ↗

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