Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype.

International journal of cancer - 2 Dec 1992

Chang S E, Foster S, Betts D, Marnock W E

Abstract excerpt

There are many reports of cell lines being established from human oral squamous-cell carcinomas but apparently none of cell lines from dysplastic or "pre-malignant" oral mucosa. We describe here the isolation and characterization of a cell line, DOK (dysplastic oral keratinocyte), from a piece of dorsal tongue showing epithelial dysplasia. The tissue was obtained from a 57-year-old man who was a heavy smoker...

Topics

Animals
Cell Line
Cell Transformation, Neoplastic
Genes, ras
Humans
Karyotyping
Keratinocytes
Male
Mice
Mice, Nude
Middle Aged
Mouth Mucosa

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mouth Neoplasms

Phenotype

Precancerous Conditions

Source

Identifiers

PMID: 1459732
DOI: 10.1002/ijc.2910520612

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1459732-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed non-malignant phenotype.PMID 1459732Read ↗

Creating oral squamous cancer cells: A cellular model of oral–esophageal carcinogenesisSemantic proximity Read ↗

Establishment and characterization of Asian oral cancer cell lines as in vitro models to study a disease prevalent in AsiaSemantic proximity Read ↗

Characterization of newly established oral cancer cell lines derived from six squamous cell carcinoma and two mucoepidermoid carcinoma cells.Semantic proximity Read ↗

Three distinct keratinocyte subtypes identified in human oral epithelium by their patterns of keratin expression in culture and in xenograftsSemantic proximity Read ↗

The p53 status of cultured human premalignant oral keratinocytes.Semantic proximity Read ↗

Multiple genotypic aberrances associate to terminal differentiation-deficiency of an oral squamous cell carcinoma in serum-free culture.Semantic proximity Read ↗

Immortalization of normal human gingival keratinocytes and cytological and cytogenetic characterization of the cells.Semantic proximity Read ↗

A mouse model of human oral-esophageal cancer.Semantic proximity Read ↗

Establishment of OC3 oral carcinoma cell line and identification of NF‐κB activation responses to areca nut extractSemantic proximity Read ↗

The phenotype of in vitro reconstituted normal human oral epithelium is essentially determined by culture medium.Semantic proximity Read ↗

Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1.Semantic proximity Read ↗

Overexpression of JunB in undifferentiated malignant rat oral keratinocytes enhances the malignant phenotype in vitro without altering cellular differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.