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Genetic analysis of the CYP2D6 locus in a Hong Kong Chinese population.

Clinical chemistry - 1 Jan 2000

Garcia-Barceló M, Chow L Y, Chiu H F, Wing Y K, Lee D T, Lam K L, Waye M M

Abstract excerpt

BACKGROUND: The cytochrome P450 CYP2D6 enzyme debrisoquine 4-hydroxylase metabolizes many different classes of commonly used drugs, such as tricyclic antidepressants and neuroleptics. Genetic polymorphism of the CYP2D6 gene is responsible for pronounced interindividual and interracial differences in the metabolism of these drugs. The CYP2D6*10 allele and its variants are the most frequent alleles found in...

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PMID: 10620567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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