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Article

Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse.

BMC cancer - 7 Feb 2018

Mervai Zsolt, Egedi Krisztina, Kovalszky Ilona, Baghy Kornélia

Abstract excerpt

BACKGROUND: Diethylnitrosamine is a well known carcinogen that induces cancers of various organs in mice and rats. Using FVB/N mouse strain, here we show that diethylnitrosamine induces primarily lung adenocarcinomas with modest tumor development in the liver, offering a new model to study chemical carcinogenesis in the lung. METHODS: Animals were exposed to a single high dose of diethylnitrosamine, and more than...

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Identifiers

PMID: 29415661
DOI: 10.1186/s12885-018-4068-4
PMCID: PMC5803903

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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