A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis.

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Article

A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis.

Clinical and experimental rheumatology - 1 Jan 2000

Ju L Y, Paolozzi L, Delecoeuillerie G, Bourgeois P, Khodja M, Legoff P, Liote F, Sheffer V, Amor B, Charron D

Abstract excerpt

To investigate the relationship between HLA class II genotypes and toxic intolerance during treatment with Tiopronin, a slow-acting drug used in the treatment of rheumatoid arthritis (RA), we studied 40 patients who were divided into two groups: a group of 22 patients without side effects and a group of 18 patients with intolerance to Tiopronin. The PCR-RFLP method was used to determine the HLA-DR, DQ and DP...

Topics

Adult
Aged
Alleles
Arthritis, Rheumatoid
Base Sequence
DNA
Drug Hypersensitivity
Female
Genetic Linkage
Genotype
HLA-DP Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HLA-DP beta-Chains

HLA-DQ Antigens

HLA-DQ alpha-Chains

HLA-DQ beta-Chains

HLA-DR Antigens

HLA-DRB1 Chains

HLA-DRB4 Chains

Source

Open in PubMed

Identifiers

PMID: 7915222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7915222-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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