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Article

[The associations between idiosyncratic adverse drug reactions and HLA alleles and their underlying mechanism].

Yao xue xue bao = Acta pharmaceutica Sinica - 1 Jun 2013

Wang Qing, Mei Hu, Zhang Ya-Lan, Pan Xian-Chao, Tan Wen, Chao Li

Abstract excerpt

With the advent of Twenty-First century, more and more genome-wide association studies (GWAS) showed that idiosyncratic adverse drug reactions (ADRs) were closely related with human leukocyte antigen (HLA) alleles, such as the associations of abacavir-HLA-B*5701, allopurinol-HLA-B*5801, and carbamazepine-HLA-B*1502, etc. To explore the mechanisms of these idiosyncratic drug reactions, hapten hypothesis, danger...

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PMID: 23984511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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