Article
HLA-DR1-positive patients suffering from rheumatoid arthritis are at high risk for developing mucocutaneous side effects upon gold therapy.
Human immunology - 1 Oct 1993
Pickl W F, Fischer G F, Faé I, Kolarz G, Scherak O
Abstract excerpt
Population studies suggest an association between RA and, depending on the ethnic background, HLA-DR1 and/or -DR4. One standard regimen for the treatment of RA is the use of gold compounds like SATM to arrest progression of the disease. In the present study, the immunogenetic background of RA patients developing side effects upon SATM treatment was determined. A total of 53 patients under SATM therapy were tested...
Topics
- Adult
- Arthritis, Rheumatoid
- Genetic Predisposition to Disease
- Gold Sodium Thiomalate
- HLA-DQ Antigens
- HLA-DR1 Antigen
- Humans
- Middle Aged
- Mucous Membrane
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length