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Article

Addressing Doxorubicin Resistance in Bone Sarcomas Using Novel Drug-Resistant Models

8 Jun 2022

Abstract excerpt

Bone sarcomas have not shown a significant improvement in survival for decades, due, in part, to the development of resistance to current systemic treatments, such as doxorubicin. To better understand those mechanisms mediating drug-resistance we generated three osteosarcoma and one chondrosarcoma cell lines with a stable doxorubicin-resistant phenotype, both in vitro and in vivo. These resistant strains include...

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PMID: 35742867
DOI: 10.3390/ijms23126425

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