Article
In vivo selection during pefloxacin therapy of a mutant of Staphylococcus aureus with two mechanisms of fluoroquinolone resistance.
Antimicrobial agents and chemotherapy - 1 May 1994
Tankovic J, Desplaces N, Duval J, Courvalin P
Abstract excerpt
Staphylococcus aureus BM4626 (ciprofloxacin MIC, 0.5 microgram/ml) and BM4627 (ciprofloxacin MIC, 32 microgram/ml) were isolated from the same patient before and during pefloxcin therapy for septic tibial nonunion, respectively. The two strains had similar serotypes and indistinguishable phage ty...
Topics
- Anti-Infective Agents
- Bacteriophage Typing
- Base Sequence
- Drug Resistance, Microbial
- Electrophoresis, Polyacrylamide Gel
- Humans
- Molecular Sequence Data
- Mutation
- Norfloxacin
- Pefloxacin
- Polymorphism, Restriction Fragment Length
- Serotyping
- Staphylococcal Infections
- Staphylococcus aureus